Two gates stand between you and the interior, and the first is the boat. The fort is only reachable from the seasonal Ship Island ferry out of Gulfport, from a private boat or from a charter. No ferry, no fort.
The second is the opening pattern. The interior is opened on a limited schedule rather than all day, and recent postings have run Wednesday to Sunday across a short midday window in season. Land on a Monday or a Tuesday and you may find yourself photographing the outside of a locked building. Check the current pattern with the Park Service before you pick your sailing, particularly if the fort is the reason you are going.
When it is open, ranger-led talks run and are worth arranging your day around — this is a site where the interpretation does much more than the building. Allow twenty to forty minutes inside, longer with a talk.
Physically it is manageable for most people: the ground floor is broadly level, though the surface is uneven brick and sand and there are steps at the entrance. There is no lift, no lighting beyond daylight through the embrasures, and no facilities inside. The restrooms and the shade are back across the boardwalk at the swim beach.